2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-111953
    SR-4559 847939-23-5 98.81%
    SR-4559 is a α/β hydrolase domain-containing protein 5 (ABHD5) ligand. SR-4559 activates adipose triglyceride lipase (ATGL) and stimulates lipolysis by inhibiting ABHD5-PLIN interactions in adipocytes and muscle cells. SR-4559 can be used for metabolic diseases like Chanarin Dorfman syndrome research.
    SR-4559
  • HY-113836
    3-Hydroxyhexanoic acid 10191-24-9
    3-Hydroxyhexanoic acid is an ester product.
    3-Hydroxyhexanoic acid
  • HY-120964
    N-Stearoyl Taurine 63155-80-6 99.00%
    Several different arachidonoyl amino acids, including N-arachidonoyl dopamine (NADA) and N-arachidonoyl serine (ARA-S), have been isolated and characterized from bovine brain.1 During mass spectral lipidomic analysis of rat brain, a series of fatty acyl amides of a third amino acid, taurine, is discovered.2 This novel class of compounds is present in kidney and activates members of the transient receptor potential (TRP) family of calcium channels.3 N-Stearoyl taurine is a prominent amino-acyl endocannabinoid isolated from rat brain during lipidomics profiling.
    N-Stearoyl Taurine
  • HY-125083
    Lys-D-Pro-Thr 117027-34-6 99.63%
    Lys-D-Pro-Thr, an IL-1beta analogue (Positions 193-195), is a potent IL-1 inhibitor.
    Lys-D-Pro-Thr
  • HY-131492
    Δ4-Dafachronic acid 23017-97-2
    Δ4‑Dafachronic acid is an endogenous steroid hormone, an agonist of the DAF‑12 nuclear receptor, and a key ligand for the vitamin D receptor (VDR). Δ4‑Dafachronic acid promotes the active escape developmental trajectory in Austrofundulus limnaeus embryos even under diapause‑inducing conditions. Δ4‑Dafachronic acid is suitable for research on the developmental biology.
    Δ4-Dafachronic acid
  • HY-131516
    Tiopronin-cysteine disulfide 77591-18-5
    Tiopronin-cysteine disulfide is a soluble disulfide metabolite/derivative of Tiopronin (HY-B0373) formed by reaction of Tiopronin with cystine. Tiopronin-cysteine disulfide reduces cystine crystal formation in cystinuria. Tiopronin-cysteine disulfide can be used for the research of cystinuria.
    Tiopronin-cysteine disulfide
  • HY-133890
    Tauro-α-muricholic acid 25613-05-2 99.18%
    Tauro-α-muricholic acid (T-α-MCA) is a Taurine (HY-B0351)-conjugated primary Bile acid. Tauro-α-muricholic acid is a FXR antagonist with an IC50 of  28 µM. Tauro-α-muricholic acid attenuates other bile acid-activated FXR signaling. Tauro-α-muricholic acid can be used in the research of Alzheimer's disease, glucose metabolism, and lipid metabolism.
    Tauro-α-muricholic acid
  • HY-145505
    1-Oleoyl-2-hydroxy-sn-glycero-3-PG sodium 326495-24-3 99.0%
    1-Oleoyl-2-hydroxy-sn-glycero-3-PG (18:1 Lyso PE) sodium is a lysophospholipid containing oleic acid (18:1) at the sn-1 position. It can be used in the generation of micelles, liposomes, and other types of artificial membranes, including lipid-based drug carrier systems.
    1-Oleoyl-2-hydroxy-sn-glycero-3-PG sodium
  • HY-145507
    1-Palmitoyl-2-hydroxy-sn-glycero-3-phospho-(1'-rac-glycerol) sodium 326495-22-1 99.0%
    1-Palmitoyl-2-hydroxy-sn-glycero-3-phospho-(1'-rac-glycerol) (16:0 Lyso PE) sodium is a lysophospholipid containing palmitic acid (16:0) at the sn-1 position. It can be used in the generation of micelles, liposomes, and other types of artificial membranes, including lipid-based drug carrier systems.
    1-Palmitoyl-2-hydroxy-sn-glycero-3-phospho-(1'-rac-glycerol) sodium
  • HY-148757
    TIM-063 2493978-38-2
    TIM-063 is a selective and cell-permeable CaMKK inhibitor, ATP competitive inhibitor, can directly target the catalytic domain of CaMKK, with the Ki values of 0.35 μM and 0.2 μM for CaMKKα and CaMKKβ, respectively, the IC50 values are 0.63 μM and 0.96 μM, respectively.
    TIM-063
  • HY-163771
    Pyruvate Carboxylase-IN-5 3047101-14-1 98.92%
    Pyruvate Carboxylase-IN-5 (compound 6m) is a pyruvate carboxylase inhibitor with high selectivity and permeability. Pyruvate carboxylase is a mitochondrial enzyme that catalyzes the carboxylation of pyruvate to oxaloacetate, a process that plays an important role in maintaining steady-state levels of Krebs cycle intermediates, which are precursors for the synthesis of biomacromolecules such as amino acids, fatty acids, and glucose.
    Pyruvate Carboxylase-IN-5
  • HY-171036
    GAPDH-IN-1 252212-58-1 98.10%
    GAPDH-IN-1 (Compound F8) is a GAPDH inhibitor (IC50 of 39.31 μM for GAPDH enzymatic activity). GAPDH-IN-1 forms a covalent adduct with an aspartic acid in the active site to displace NAD+, a cofactor of the enzyme, with concomitant enhancement of the cysteine-reactive probe reaction with the catalytic cysteine.
    GAPDH-IN-1
  • HY-171454
    DA-1241 1914136-10-9 99.18%
    DA-1241 is a GPR119 agonist. DA-1241 reduces macrophage differentiation through downregulation of NFκB signaling by activating GPR119. DA-1241, alone and in combination with a DPP4 inhibitor, reduces liver inflammation and restores inflammation-related liver gene expression. DA-1241 can be used for the research of metabolic dysfunction-associated steatohepatitis (MASH).
    DA-1241
  • HY-B0710S
    Betaine-13C3 309762-22-9 99.86%
    Betaine-13C3 (Trimethylglycine-13C3) is the 13C labeled isotope of Betaine (HY-B0710). Betaine (Trimethylglycine) is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns[1,2]. Betaine is found ubiquitously in plants, animals, microorganisms, and rich dietary sources including seafood, spinach, and wheat bran. Betaine also acts as an osmolyte, to maintain the avian’s cellular water and ion balance to improve the avian’s capacity against heat stress via preventing dehydration and osmotic inactivation. It helps in maintaining the protective osmolytic activity, especially in heat-stressed birds. Betaine may promote various intestinal microbes against osmotic variations and thus improve microbial fermentation activity.
    Betaine-13C3
  • HY-B2219A
    Calcium stearate 1592-23-0
    Calcium stearate is an orally active long-chain dietary saturated fatty acid that can significantly reduce visceral fat by inducing apoptosis of preadipocytes. Calcium stearate can be used in the study of cardiovascular and metabolic diseases.
    Calcium stearate
  • HY-N0853A
    Alisol A 24-acetate 18674-16-3 98.0%
    Alisol A 24-acetate (Alisol A monoacetate) is an orally active derivative of protostane-type tetracyclic triterpenoid. Alisol A 24-acetate upregulates the expression of adiponectin, AMPKα, CPT1, and ACOX1; downregulates the expression of SREBP-1c, ACC, FAS, Bcl-2, Bcl-xl, PPAR-γ, perilipin A, and NFATc1; inhibits the activity of PI3K/Akt/mTOR and HMGR; and activates the PKA and ERK signaling pathways. Alisol A 24-acetate regulates cell apoptosis (apoptosis), autophagy (Autophagy, hepatic lipid accumulation, inflammatory response, neuroprotection, MRSA membrane integrity, and osteoclast differentiation. Alisol A 24-acetate can be used in research related to non-alcoholic fatty liver disease, nephrotoxicity, obesity, global cerebral ischemia-reperfusion injury, bacterial infection, and osteoporosis.
    Alisol A 24-acetate
  • HY-N11678
    Deoxynivalenol-3-β-D-glucoside 131180-21-7
    Deoxynivalenol-3-β-D-glucoside (DON-3-β-D-glucoside) is a plant metabolite of the Fusarium mycotoxin Deoxynivalenol (HY-N6684). Deoxynivalenol-3-β-D-glucoside exhibits lower toxicity than Deoxynivalenol in vitro and in vivo.
    Deoxynivalenol-3-β-D-glucoside
  • HY-N11908
    α-Santalol 115-71-9
    α-Santalol (cis-α-Santalol), a naturally occurring sesquiterpene, is an orally active anticancer agent and apoptosis inducer. α-Santalol activates caspase-3 to drive apoptotic processes. >α-Santalol induces apoptosis, decreases cell viability, and causes PARP cleavage in human prostate cancer cells. α-santalol inhibits Akt/Survivin pathway to induce cell death. α-Santalol can be used for the research of prostate cancer and diabetes mellitus.
    α-Santalol
  • HY-Y0504R
    Trimethylammonium chloride (Standard) 593-81-7 99.49%
    Trimethylammonium chloride (Standard) is the analytical standard of Trimethylammonium chloride. This product is intended for research and analytical applications. Trimethylammonium chlorideIt is an endogenous metabolite that inhibits deacetylation. Trimethylammonium chlorideIs a non-competitive inhibitor of acetylcholinesterase.
    Trimethylammonium chloride (Standard)
  • HY-Y0889A
    1-(2,3-Dichlorphenyl)piperazine hydrochloride 119532-26-2 99.98%
    1-(2,3-Dichlorphenyl)piperazine hydrochloride is a potent DHCR7 inhibitor with the activity of inhibiting cholesterol biosynthesis. 1-(2,3-Dichlorphenyl)piperazine hydrochloride is often used in biological research to evaluate the function of cholesterol biosynthesis pathway. The application of 1-(2,3-Dichlorphenyl)piperazine hydrochloride is of great significance for understanding diseases related to cholesterol biosynthesis.
    1-(2,3-Dichlorphenyl)piperazine hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity